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Bioinorganic Chemistry: Cellular Systems and Synthetic Models


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Bioinorganic Chemistry: Cellular Systems and Synthetic Models
Oxford University Press, USA | 2009-06-19 | ISBN: 0841269750 | 264 pages | File type: PDF | 23.5 mb

Bioinorganic Chemistry: Cellular Systems and Synthetic Models includes chapters describing cutting-edge work by renowned researchers in the field that fall within two main areas of current bioinorganic chemistry: (1) the study of cellular systems and processes that occur inside cells that are impacted by inorganic elements, e.g., biosynthetic pathways leading to the production of vital metal-containing enzymes and proteins including iron-sulfur clusters, hemes, and cytochrome c oxidase; metal homeostasis (Zn2 in E. coli); and new strategies to examine DNA targeting by metal-based drugs using, as an example, the clinically-employed bleomycin class of antitumor agents, and (2) sophisticated new inorganic model systems, many of which escape the traditional approach of trying to use structural mimics of the native systems to produce functional mimics and instead use a more conceptual approach to the use of bioinorganic models to understand the native system or to develop useful synthetic molecules.
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